CD7-targeting tLNPs for T-cell and NK delivery.

In a recent comparative study of T-cell targeting moieties (including CD2, CD4, CD5, CD7, and CD8), CD7-targeting tLNPs consistently demonstrated the highest mRNA delivery efficiency and functional CAR T-cell generation both in vitro and in vivo (Zeng et al., 2026). 

The primary driver behind this superiority is receptor internalization dynamics: 

• Internalization Over Abundance: Mechanistic analysis revealed that rapid, intrinsic receptor endocytosis, rather than baseline target expression levels on the T-cell surface, serves as the primary rate-limiting factor for successful tLNP cytosolic mRNA delivery. 

• Clone-Independent Trait: This rapid internalization is an intrinsic physiological property of the CD7 receptor itself, rendering the delivery advantage largely independent of the specific antibody clone or binding motif utilized. 

To enable quick testing of CD7-targeting mRNA/DNA delivery, Tiva Bio now provides ready-to-use tools: 

CD7-eGFP-tLNPs: Pre-formulated reference controls (>90% transfection to CD4+ T, CD8+ T and NK cells) for immediate benchmarking  

Ready-to-Target CD7 kit: To transform your existing LNPs into CD7-targeting by simple mixing 

Reach out to learn more.  

References 

Zeng, J. et al. (2026). Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and in vivo CAR T-cell engineering. Journal of Controlled Release, 115043. https://doi.org/10.1016/j.jconrel.2026.115043