Tools for Targeted-LNPs: Plug-and-Play Simplicity vs in vivo Potency

A recent study highlighted a seamless strategy for producing antibody-mRNA LNPs by pairing post-encapsulation of mRNA into empty LNPs with post-insertion of ligand-conjugated PEG-lipids. https://lnkd.in/gRWmfQcx

At Tiva Biosciences, our Ready-to-Target research kits have utilized similar principles since 2025 (CD3, CD7, CD8 and counting). Our internal observations and client data match the study’s findings:
🔹 Post-insertion: Highly convenient, modular, and fast for broad screening
🔹 Direct on-particle conjugation: Consistently superior functional payload delivery and expression

Plug-and-play formulations are fantastic for early-stage discovery, but direct conjugation remains the gold standard when driving maximum in vivo activity.